Society for Neuroscience Satellite Meeting
Neurotoxic Mechanisms in Alzheimer's Disease
Organizers: Lary Walker (Emory University)
and Richard M. Kostrzewa (East Tennessee State University) 

 

Sponsored by Neuroscience Associates
Premier Neurohistology Services and Products
www.NeuroscienceAssociates.com
and
Emory Alzheimer's Disease Research Center

Friday, October 13, 08.30-17.00 h
Emory University
Yerkes National Primate Research Center, Main Seminar Room
954 Gatewood Road
Atlanta, GA 30322 

 The neurotoxic events leading to dementia in Alzheimer's disease (AD) are critically dependent on abnormalities of the peptide Abeta, but how Abeta contributes to cellular dysfunction remains incompletely understood. Interactions of Abeta with tau and other cellular proteins hold important clues, and the evidence increasingly implicates small oligomers of Abeta in cytopathic phenomena. In this satellite symposium, experts in AD and related proteopathies will explore the mechanisms involved in the neurotoxicity of AD, as well as some potential therapeutic strategies suggested by our growing understanding of the pathogenic process.

Preliminary Program 

8:30-9:30       Registration (Main Lobby, Yerkes Center)

Session I  Cellular Neurotoxic and Neuroprotective Mechanisms in Alzheimer’s Disease

Chair:   LARY WALKER
9:30 MARLA GEARING (Emory University)
Cytopathology in AD: a neuropathologist's view
10:00 WILLIAM KLEIN (Northwestern University)
Abeta toxicity in AD: the role of oligomers (ADDLs)
10:30 Coffee
11:00 JAMES LAH (Emory University)
LR11 and AD
11:30 EFRAT LEVY(Nathan Kline)
The cysteine protease inhibitor cystatin C inhibits neurotoxicity in AD
12:00 GILLES J. GUILLEMIN (Univ. New South Wales)
12:30 Lunch & Tour of Yerkes

Session II  Prospects for Intervention in AD

Chair:  JAMES LAH
1:45 FRANK LAFERLA (Univ California at Irvine) 
Intracellular toxicity of Abeta and tau
2:15 JORGE GHISO (New York University) 
Effects of post-translational modifications in amyloid toxicity
2:45  Coffee
3:15 TODD GOLDE (Mayo, Jacksonville)
Rapid in vivo paradigms for evaluating candidate neuronal death pathways
relevant to neurodegenerative diseases
3:45  ELIEZER MASLIAH (Univ. California, San Diego)
Neuroprotective gene therapy approaches for Alzheimer disease
4:15 Open Discussion
4:45 Adjourn

 

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